Increased Nitrotyrosine in Exhaled Breath Condensate of Patients with Asthma
نویسندگان
چکیده
منابع مشابه
Increased nitrotyrosine in exhaled breath condensate of patients with asthma.
The reaction of nitric oxide (NO) and superoxide anions (O(2)(-)) in the airway results in the formation of peroxynitrite, a highly reactive oxidant species. Peroxynitrite reacts with tyrosine residues in proteins to form the stable product nitrotyrosine. We investigated whether nitrotyrosine in exhaled breath condensates may be increased in patients with asthma. Four groups of nonsmoking subje...
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Exhaled nitric oxide (ENO), a marker of inflammation in airway diseases is decreased in cystic fibrosis (CF) patients, perhaps because nitric oxide (NO) is metabolized to oxidative end-products. A stable product, 3-nitrotyrosine, may indicate local formation of reactive nitrogen species. Whether NO metabolites in exhaled breath condensate may be increased in CF patients was investigated. The fr...
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Drug abuse is a serious problem causing health, economical and psycho-social negative outcomes. Methadone is commonly used drug for management of drug addiction. Exhaled breath condensate (EBC) is a promising non-invasive biological sample which attracted more attention in recent years. This work aimed to extend the applicability of a developed preconcentration – liquid chromatographic method f...
متن کاملSafety and success of exhaled breath condensate collection in asthma.
BACKGROUND Exhaled breath condensate (EBC) is a rapidly expanding area of research to study airway inflammation through the detection of volatile and non-volatile substances in the airways. AIMS To determine the safety and feasibility of EBC procedure in a group of children with asthma of varying severity. METHODS In a cross sectional study of children aged 4-17 years, 18 healthy and 91 ast...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2000
ISSN: 1073-449X,1535-4970
DOI: 10.1164/ajrccm.162.4.9912064